Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation
作者： Cheng Zhang , Dan Chen , Eithne Margaret Maguire , Shiping He , Jiangyong Chen
DOI: 10.1093/CVR/CVX236
关键词: Vascular smooth muscle 、 Receptor 、 Research centre 、 Vascular pathology 、 Cell growth 、 Cell migration 、 Myocyte 、 Molecular biology 、 Chemistry 、 Neointima 、 Physiology (medical) 、 Physiology 、 Cardiology and Cardiovascular Medicine
摘要: Aims To investigate the role of chromobox protein homolog 3 (Cbx3) in vascular smooth muscle cell (VSMC) proliferation, migration, and neointima formation following vascular injury. Methods and results Overexpression of Cbx3 led to a significant increase in VSMC contractile gene expression and VSMC apoptosis as well as a dramatic decrease in collagen gene expression, VSMC proliferation, and migration. Meanwhile, the opposite was observed following inhibition of endogenous Cbx3. Luciferase activity assays revealed that …
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Wenwen Wu, Hiroyuki Nishikawa, Takayo Fukuda, Vinayak Vittal, Masahide Asano, Yasuo Miyoshi, Rachel E. Klevit, Tomohiko Ohta, Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage. Cancer Research. ,vol. 75, pp. 1311- 1321 ,(2015) , 10.1158/0008-5472.CAN-14-2796
Maya Ameyar-Zazoua, Christophe Rachez, Mouloud Souidi, Philippe Robin, Lauriane Fritsch, Robert Young, Nadya Morozova, Romain Fenouil, Nicolas Descostes, Jean-Christophe Andrau, Jacques Mathieu, Ali Hamiche, Slimane Ait-Si-Ali, Christian Muchardt, Eric Batsché, Annick Harel-Bellan, Argonaute proteins couple chromatin silencing to alternative splicing Nature Structural & Molecular Biology. ,vol. 19, pp. 998- 1004 ,(2012) , 10.1038/NSMB.2373
M W Liu, G S Roubin, S B King, Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation. ,vol. 79, pp. 1374- 1387 ,(1989) , 10.1161/01.CIR.79.6.1374
Y Akaike, Y Kuwano, K Nishida, K Kurokawa, K Kajita, S Kano, K Masuda, K Rokutan, Homeodomain-interacting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1γ. Oncogene. ,vol. 34, pp. 3463- 3473 ,(2015) , 10.1038/ONC.2014.278
Ji Zhou, Hui Bi, Ping Zhan, Cunjie Chang, Chunhua Xu, Xiaojing Huang, Like Yu, Xin Yao, Jun Yan, Overexpression of HP1γ is associated with poor prognosis in non-small cell lung cancer cell through promoting cell survival Tumor Biology. ,vol. 35, pp. 9777- 9785 ,(2014) , 10.1007/S13277-014-2182-8
S. Canudas, B. R. Houghtaling, M. Bhanot, G. Sasa, S. A. Savage, A. A. Bertuch, S. Smith, A role for heterochromatin protein 1γ at human telomeres Genes & Development. ,vol. 25, pp. 1807- 1819 ,(2011) , 10.1101/GAD.17325211
Aurélie Bedel, Anne Nègre-Salvayre, Sylvia Heeneman, Marie-Hélène Grazide, Jean-Claude Thiers, Robert Salvayre, Françoise Maupas-Schwalm, E-Cadherin/β-Catenin/T-Cell Factor Pathway Is Involved in Smooth Muscle Cell Proliferation Elicited by Oxidized Low-Density Lipoprotein Circulation Research. ,vol. 103, pp. 694- 701 ,(2008) , 10.1161/CIRCRESAHA.107.166405
Alessandra Granata, William G. Bernard, Ning Zhao, John Mccafferty, Brenda Lilly, Sanjay Sinha, Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. Stem Cells and Development. ,vol. 24, pp. 846- 856 ,(2015) , 10.1089/SCD.2014.0520
C. Fouillade, M. Monet-Lepretre, C. Baron-Menguy, A. Joutel, Notch signalling in smooth muscle cells during development and disease Cardiovascular Research. ,vol. 95, pp. 138- 146 ,(2012) , 10.1093/CVR/CVS019
A ZADELAAR, J THUSEN, L MBOESTEN, R HOEBEN, M KOCKX, M VERSNEL, T VANBERKEL, L HAVEKES, E LBIESSEN, B VANVLIJMEN, Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer. Atherosclerosis. ,vol. 183, pp. 244- 250 ,(2005) , 10.1016/J.ATHEROSCLEROSIS.2005.03.044