Inducible secretion of large, biologically potent von Willebrand factor multimers

摘要: von Willebrand factor (vWf) secreted constitutively by human endothelial cells was compared to that released from Weibel-Palade bodies after stimulation. The majority of molecules were dimeric and contained both pro-vWf mature subunits. In contrast, the vWf calcium ionophore A23187 or thrombin consisted only very large multimers are known be more active in vitro platelet binding assays, their absence vivo results a bleeding disorder. Endothelial therefore concentrate special subclass biologically potent bodies, presumably available for release response vascular injury.