Time to fight: targeting the circadian clock molecular machinery in cancer therapy.
作者： Matteo Astone , Massimo M. Santoro
DOI: 10.1016/J.DRUDIS.2021.01.023
关键词: Cancer therapy 、 Circadian rhythm 、 Tumor growth 、 CLOCK 、 Neuroscience 、 Biology 、 Cancer 、 Tumor initiation 、 Circadian clock
摘要: The circadian clock regulates a wide range of molecular pathways and biological processes. expression genes is often altered in cancer, fostering tumor initiation progression. Inhibition activation core genes, as well treatments that restore rhythmicity, have been successful counteracting growth different experimental models. Here, we provide an up-to-date overview studies show the therapeutic effects targeting machinery both genetically pharmacologically. We also highlight future areas for progress offer promising path towards innovative anticancer strategies. Substantial limitations current understanding complex interplay between cancer vivo need to be addressed order allow clock-targeting therapies cancer.
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