GABA Receptor Pharmacology
DOI: 10.1007/978-3-0348-7218-8_2
关键词: GABA receptor 、 Receptor 、 GABAA-rho receptor 、 Chemistry 、 GABA analogue 、 GABAA receptor 、 GABAB receptor 、 Pharmacology 、 Bicuculline 、 GABA receptor antagonist
摘要: There is increasing evidence for the existence of “novel” receptors neurotransmitter GABA that pharmacologically fall outside currently accepted classification two major subtypes. The GABAA/B classification, introduced in 1981, defines GABAA as being sensitive to antagonism by bicuculline and insensitive baclofen, while GABAB are activated baclofen.
springer.com
springerlink.com参考文章(21)
E. Sigel, R. Baur, S. Kellenberger, P. Malherbe, Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels. The EMBO Journal. ,vol. 11, pp. 2017- 2023 ,(1992) , 10.1002/J.1460-2075.1992.TB05258.X
H Qian, JE Dowling, Pharmacology of novel GABA receptors found on rod horizontal cells of the white perch retina The Journal of Neuroscience. ,vol. 14, pp. 4299- 4307 ,(1994) , 10.1523/JNEUROSCI.14-07-04299.1994
R Miledi, R M Woodward, L Polenzani, Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonists and antagonists. Molecular Pharmacology. ,vol. 43, pp. 609- 625 ,(1993)
G Matthews, GS Ayoub, R Heidelberger, Presynaptic inhibition by GABA is mediated via two distinct GABA receptors with novel pharmacology The Journal of Neuroscience. ,vol. 14, pp. 1079- 1090 ,(1994) , 10.1523/JNEUROSCI.14-03-01079.1994
F. Nagy, C. Jackel, W.-D. Krenz, BICUCULLINE/BACLOFEN-INSENSITIVE GABA RESPONSE IN CRUSTACEAN NEURONES IN CULTURE The Journal of Experimental Biology. ,vol. 191, pp. 167- 193 ,(1994) , 10.1242/JEB.191.1.167
Colleen A. Drew, Graham A.R. Johnston, Robert P. Weatherby, Bicuculline-insensitive GABA receptors: Studies on the binding of (−)-baclofen to rat cerebellar membranes Neuroscience Letters. ,vol. 52, pp. 317- 321 ,(1984) , 10.1016/0304-3940(84)90181-2
G. Bonanno, M. Raiteri, Multiple GABAB receptors. Trends in Pharmacological Sciences. ,vol. 14, pp. 259- 261 ,(1993) , 10.1016/0165-6147(93)90124-3
Rujee K. Duke, Robin D. Allan, Colleen A. Drew, Graham A. R. Johnston, Kenneth N. Mewett, Mervyn A. Long, Chit Than, The preparation of tritiated E- and Z-4-aminobut-2-enoic acids, conformationally restricted analogues of the inhibitory neurotransmitter 4-aminobutanoic acid (GABA) Journal of Labelled Compounds and Radiopharmaceuticals. ,vol. 33, pp. 527- 540 ,(1993) , 10.1002/JLCR.2580330610
Andreas Feigenspan, Heinz Wässle, Joachim Bormann, Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells. Nature. ,vol. 361, pp. 159- 162 ,(1993) , 10.1038/361159A0
G. A. R. Johnston, D. R. Curtis, P. M. Beart, C. J. A. Game, R. M. Mcculloch, B. Twitchin, Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. Journal of Neurochemistry. ,vol. 24, pp. 157- 160 ,(1975) , 10.1111/J.1471-4159.1975.TB07642.X