First-trimester maternal serum matrix metalloproteinase-9 (MMP-9) and adverse pregnancy outcome

摘要: Objective To investigate the potential value of maternal serum matrix metalloproteinase-9 (MMP-9) in first-trimester screening for preeclampsia and spontaneous early preterm delivery. Methods The concentrations MMP-9, tumour necrosis factor soluble receptor-1 (TNF-R1), pregnancy-associated plasma protein-A (PAPP-A) uterine artery pulsatility index (UA-PI) were measured at 11+0 − 13+6 weeks cases (n = 128), gestational hypertension 88), small age 296), delivery 57) controls 569). The distributions metabolites UA-PI control adverse outcome groups compared. Logistic regression analysis was used to determine significant contributors prediction outcomes. Results The median MMP-9 higher than (1.190 MoM) (1.187 groups. In group there a association between TNF-R1 (r 0.523, P < 0.0001). Significant provided by history UA-PI, neither improved addition MMP-9. Conclusion In pregnancies developing preeclampsia, increased level good correlation with suggest presence an underlying inflammatory process. resulting increase is not useful delivery. Copyright © 2009 John Wiley & Sons, Ltd.