Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy : Association of immune activation, T cell maturation markers, and cellular HIV-1 DNA

摘要: Background. Suboptimal CD4 + T cell recovery during antiretroviral therapy (ART) is a common clinical dilemma. Methods. We analyzed viral and immunologic predictors of in 116 human immunodeficiency virus type 1 (HIV-1)-infected subjects who had suppressed viremia (≤50 copies/mL) while receiving ART. Successive measurements immunophenotypes cellular HIV-1 DNA levels were obtained before receipt On the basis increases count, classified as immunologically concordant (demonstrating an increase ≥100 cells/mm 3 ) or discordant <100 after 48 weeks Results. In adjusted analyses, CD8 activation at baseline was negatively associated with concordance week ART (odds ratio [OR], 0.80 [P =.04] 0.67 =.02], respectively). High memory (CDRA - CD62L counts (OR, 0.33 =.05]) predicted less recovery, whereas increased naive higher cells 1.19 =.052]). Neither cell-associated level (P =.32) nor =.42) Conclusions. These results support potential usefulness determination immune maturation subsets prediction suppression. Furthermore, identification individuals reduced for may provide rationale initiation early some patients.