Approach for Dispersing a Hydrophilic Compound as Nanoparticles Into Soybean Oil Using Evaporation Technique

摘要: Most popular formulation dispersing a hydrophilic compound into oil phase such as soybean is emulsions. An emulsion dispersed system that consists of water, oil, and surfactant. In general, apparatuses an emulsifier, homogenizer, etc. are used for the preparation. As pharmaceutical trial to disperse water-soluble compounds in phase, form very important. Namely, preparations containing hydrophil‐ ic drug uniformly water-in-oil (w/o) water-in-oil-in-water (w/o/w) emulsions preferred. these cases, molecules must retain high-density water emulsion; doing so depends on oil-to-wa‐ ter partition coefficient drug. Furthermore, decreasing particle size necessary. Much technical information about adjusting particles now available: example, rotating membrane emulsification [1, 2], shirasu po‐ rous glass [3, 4], electrocapillary [5, 6]. These meth‐ ods adjust basis pore shearing force, which flow dispersion medium or contact-surface dielectric constant differences be‐ tween phase. Therefore, technologies ad‐ vantageous they can produce uniform sizes. this chapter, simple method preparing w/o with narrow range polydispersity described. method, Polytron homogenizer evaporator apparatuses. specific ex‐ pensive were not used. Glycyrrhizin monoammonium (GZ) indocyanine green (ICG) compound. Here, behavior, stability terms prepared using novel sustained release characteristics from nano-sized investigated [7, 8].