Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease
作者： AM Saunders , C Hulette , KA Welsh-Bohmer , DE Schmechel , B Crain
DOI: 10.1016/S0140-6736(96)01251-2
关键词: Genotype 、 Central nervous system disease 、 Confidence interval 、 Alzheimer's disease 、 Predictive value of tests 、 Gastroenterology 、 Genotyping 、 Allele 、 Pathology 、 Internal medicine 、 Apolipoprotein E 、 Medicine
摘要: Summary Background We aimed to determine the specificity, sensitivity, and predictive value of apolipoprotein E (APOE) genotyping in 67 consecutive patients with clinical diagnoses sporadic Alzheimer's disease (AD) who underwent necropsy. Methods studied attended Duke Memory Disorders Clinic were diagnosed as having probable AD. These followed up until they died. APOE was done during life most cases, but some brain tissue obtained at necropsy used. Members known AD families excluded. Findings After neuropathological examination 57 (85%) our confirmed including all 43 had least one APOE-e4 allele. None found not have carried an e4 In this series, specificity allele 100%, sensitivity 75%, positive negative 42%. necropsy-confirmed e4/e4 genotype predicted 100% accuracy. The e3/e4 e2/e4 genotypes also unexpectedly highly specific for Interpretation Data from hundreds non-AD other longitudinal series will allow be assessed useful confidence limits.
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