Analysis of the Psychoactive Terpenoid Salvinorin A Content in Five Salvia divinorum Herbal Products

作者: William R Wolowich , Alisha M Perkins , John J Cienki

DOI: 10.1592/PHCO.26.9.1268

关键词: Signs and symptomsHallucinogenTerpenoidPotential riskSalvinorin ATraditional medicineMedicineSalvia divinorumSalviaProduct Label

摘要: Study Objective. To determine the content of hallucinogen salvinorin A in a variety Salvia divinorum herbal products and to compare with label claims potency purity. Design. Laboratory analysis. Setting. University-affiliated laboratory. Samples. Five containing divinorum. Measurements Main Results. The samples were purchased from Internet local drug paraphernalia shops (“head shops”). High-performance liquid chromatography thin-layer chromatography–gas chromatography–mass spectroscopy used for analysis. All five contained A, psychoactive compound found divinorum; however, concentrations we measured much lower than those claimed on product label. Vitamin E was also two caffeine one sample. Conclusion. be subpotent, three adulterants. Any discrepancy between advertised concentration their actual may pose potential risk both misuse overdose. These concerns, recently reported teenage suicide that could have been related salvia consumption, underscore need practitioners become familiar signs symptoms use.

参考文章(17)
Gail A Edelsohn, John-Paul Gomez, Psychiatric emergencies in adolescents. Adolescent Medicine Clinics. ,vol. 17, pp. 183- 204 ,(2006) , 10.1016/J.ADMECLI.2005.09.002
William A. Carlezon, Cécile Béguin, Jennifer A. DiNieri, Michael H. Baumann, Michele R. Richards, Mark S. Todtenkopf, Richard B. Rothman, Zhongze Ma, David Y.-W. Lee, Bruce M. Cohen, Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats Journal of Pharmacology and Experimental Therapeutics. ,vol. 316, pp. 440- 447 ,(2006) , 10.1124/JPET.105.092304
B. L. Roth, K. Baner, R. Westkaemper, D. Siebert, K. C. Rice, S. Steinberg, P. Ernsberger, R. B. Rothman, Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 11934- 11939 ,(2002) , 10.1073/PNAS.182234399
Jerrold B. Leikin, Anne J. Krantz, Michele Zell-Kanter, Robert L. Barkin, Daniel O. Hryhorczuk, Clinical features and management of intoxication due to hallucinogenic drugs. Medical toxicology and adverse drug experience. ,vol. 4, pp. 324- 350 ,(1989) , 10.1007/BF03259916
Douglas J. Sheffler, Bryan L. Roth, Salvinorin A: the ‘magic mint’ hallucinogen finds a molecular target in the kappa opioid receptor Trends in Pharmacological Sciences. ,vol. 24, pp. 107- 109 ,(2003) , 10.1016/S0165-6147(03)00027-0
John W. Gruber, Daniel J. Siebert, Ara H. Der Marderosian, Rick S. Hock, High performance liquid chromatographic quantification of salvinorin a from tissues ofsalvia divinorum epling & játiva-m Phytochemical Analysis. ,vol. 10, pp. 22- 25 ,(1999) , 10.1002/(SICI)1099-1565(199901/02)10:1<22::AID-PCA428>3.0.CO;2-0
Daniel J. Siebert, Salvia divinorum and salvinorin A: new pharmacologic findings Journal of Ethnopharmacology. ,vol. 43, pp. 53- 56 ,(1994) , 10.1016/0378-8741(94)90116-3
A. Pfeiffer, V. Brantl, A. Herz, H. Emrich, Psychotomimesis mediated by kappa opiate receptors Science. ,vol. 233, pp. 774- 776 ,(1986) , 10.1126/SCIENCE.3016896
L. J. ValdÉs, G. M. Hatheld, M. Koreeda, A. G. Paul, Studies ofSalvia divinorum (Lamiaceae), an Hallucinogenic mint from the Sierra Mazateca in Oaxaca, Central Mexico Economic Botany. ,vol. 41, pp. 283- 291 ,(1987) , 10.1007/BF02858975
Mark Mowry, Michael Mosher, Wayne Briner, Acute physiologic and chronic histologic changes in rats and mice exposed to the unique hallucinogen salvinorin A. Journal of Psychoactive Drugs. ,vol. 35, pp. 379- 382 ,(2003) , 10.1080/02791072.2003.10400021