Relationship of Central Pattern Generators with Parasomnias and Sleep-Related Epileptic Seizures

摘要: In 1911, Graham Brown was the first to show existence of neuronal networks within thoracic spinal cord capable producing repetitive rhythmic hind limb movements resembling locomotion. He reported that alternating locomotorlike motor were observed in antagonisticmuscles each for a short time after experimental transection an animal model had previously its dorsal sensory roots sectioned. These experiments unequivocally showed aggregates (deprived from inputs and supraspinal influences) can generate coordinated rhythmicmotormovement. Since then, wealth molecular, genetic, neuroimaging studies have confirmed such autonomous neural (now called central pattern generators [CPGs]) are present all animals. CPGs located midbrain, pons, vertebrate cord. They genetically determined (circuits) self-sustained patterns innate behaviors critical survival