Thrombospondin immune regulation and the kidney.

摘要: Most therapeutic attempts to prevent the progression of kidney diseases have been based on interventions inhibit production transforming growth factor-β (TGF-β). Thrombospondins (TSPs) play an important role in activating TGF-β. In healthy kidney, two TSPs are expressed, TSP1 and TSP2, which exert contrasting effects. While is a major activator TGF-β renal cells exerts pro-inflammatory effects both vitro vivo, TSP2 lacks ability for activation but regulates matrix remodeling inflammation experimental disease. The mostly investigated by using murine model unilateral ureteral obstruction. this model, expression increased along with development interstitial fibrosis Relief obstruction gradually improves function decreases TGF-β1. Several inhibitors prevented progressive models obstruction, suggesting that control latent inhibiting might represent novel potential target preventing fibrosis. However, further studies needed assess whether TSP1-mediated can be safely used humans. fact, normally act suppress tumors vivo. Moreover, pivotal immune system, as it may induce regulatory T B cell responses. Knowledge molecular mechanisms involved regulation help finding effective treatments tissue fibrosis, cancer autoimmune