Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease

作者: Hongpeng Jia

DOI: 10.1097/SHK.0000000000000633

关键词: DiseaseAngiotensin-converting enzyme 2VirusLungImmunologyPathogenesisMechanism (biology)ReceptorInflammationMedicineCritical Care and Intensive Care MedicineEmergency medicine

摘要: In response to infectious and, in some instances, noninfectious insults, the affected tissues/cells of host undergo inflammation. However, uncontrolled inflammation could be detrimental host, resulting inflammatory disease, such as lung disease. Although etiology disease is well defined, underling pathogenesis still incompletely understood. The renin-angiotensin system (RAS), one primary cardiovascular regulatory systems, has been proposed involved particular, RAS implicated advances understanding multifunctionality individual components have made, and by fact that acts not only systemically, but also locally a variety tissues, including lung. Angiotensin-converting enzyme 2 (ACE2), relatively new member RAS, drawn extensive attention since 2003, because findings ACE2 receptor for SARS Corona virus maintenance normal levels beneficial combat Nevertheless, mechanism through which plays role clearly identified. an attempt summarize current literature progress made uncovering this review will focus on recent studies examining pulmonary biology, its roles possible underlying mechanisms. Finally, we discuss potential therapeutic target

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