Genetic determinants of bone mineral content at the spine and radius: a twin study.
作者： J. Dequeker , J. Nijs , A. Verstraeten , P. Geusens , G. Gevers
DOI: 10.1016/8756-3282(87)90166-9
关键词: Biology 、 Anatomy 、 Age groups 、 Twin study 、 Diminution 、 Adult life 、 Heritability 、 Bone mass 、 Bone mineral content 、 Cortical bone
摘要: The possible role of genetic and/or environmental factors in determining bone mass has been investigated 30 pairs twins (16 monozygotic and 14 dizygotic) divided two age groups (below above 25 years age). Bone mineral content was evaluated by single- dual photon absorptiometry at the distol third radius for peripheral cortical lumbar spine axial bone. “within pair” variance used as an index influence. A significant (p < 0.01) determinant found adults spinal group younger than years. heritability h2 0.75 BMC 0.88 BMC. Such a could not conclusively be demonstrated adult youngsters bone, suggesting that may play more dominant growth during adolescence diminution life.
core.ac.uk
sci-hub.se 参考文章(8)
K. J. Holzinger, The relative effect of nature and nurture influences on twin differences. Journal of Educational Psychology. ,vol. 20, pp. 241- 248 ,(1929) , 10.1037/H0072484
B. Krølner, S. Pors Ntelsen, Measurement of bone mineral content (BMC) of the lumbar spine, I. Theory and application of a new two-dimensional dual-photon attenuation method. Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 40, pp. 653- 663 ,(1980) , 10.1080/00365518009091978
M. Møller, A. Horsman, B. Harvald, M. Hauge, K. Henningsen, B. E. C. Nordin, Metacarpal morphometry in monozygotic dizygotic elderly twins. Calcified Tissue International. ,vol. 25, pp. 197- 201 ,(1978) , 10.1007/BF02010768
J. R. Cameron, J. Sorenson, Measurement of Bone Mineral in vivo: An Improved Method Science. ,vol. 142, pp. 230- 232 ,(1963) , 10.1126/SCIENCE.142.3589.230
David M. Smith, Walter E. Nance, Ke Won Kang, Joe C. Christian, C. Conrad Johnston, Genetic Factors in Determining Bone Mass Journal of Clinical Investigation. ,vol. 52, pp. 2800- 2808 ,(1973) , 10.1172/JCI107476
Joe C. Christian, Testing Twin Means and Estimating Genetic Variance. Basic Methodology for the Analysis of Quantitative Twin Data Acta geneticae medicae et gemellologiae: twin research. ,vol. 28, pp. 35- 40 ,(1979) , 10.1017/S0001566000009314
Oscar Kempthorne, Richard H. Osborne, The interpretation of twin data. American Journal of Human Genetics. ,vol. 13, pp. 320- 339 ,(1961)
B. Krølner, S. Pors Ntelsen, Measurement of bone mineral content (BMC) of the lumbar spine, I. Theory and application of a new two-dimensional dual-photon attenuation method Scandinavian Journal of Clinical and Laboratory Investigation. ,vol. 40, pp. 653- 663 ,(1980) , 10.3109/00365518009091978