Regulation of Purine Biosynthesis De Novo

摘要: Hyperuricemia can result from an increase in the rate of purine biosynthesis de novo, a decrease renal clearance uric acid, or combination these two processes. The relative contribution each processes to development hyperuricemia varies with subpopulation under study. This might be expected, since gout is clinical disorder diverse etiologies. Some referral centers have reported that as many 75% their patients exhibit increased rates judged isotopic incorporation techniques (Gutman et al., 1958; Seegmiller 1961). However, experience other suggests only 15–25% primary develop due (Watts 1976). While prevalence overproduction general gouty population not known, it appears significant proportion novo. Because this association, mechanisms responsible for regulation been subject numerous studies.