Detection of Horizontal Gene Transfer in Bacterial Genomes

摘要: Most bacterial genes were acquired by horizontal gene transfer (HGT) from other prokaryotic organisms instead of being inherited continuous vertical descent an ancient ancestor. HGT is generally believed to be a major factor in microbiology evolution, allowing rapid diversification and adaptation. In this paper, we artificially simulate inserting phage into genomes, then try identify horizontally transferred normal genes. Based on nucleotide composition analyses, Nonparallel Plane Proximal Classifier (NPPC) applied predict for the first time. We also present novel method, namely VQ-NPPC, which combines Vector Quantization (VQ) NPPC. The results confirm that NPPC VQ-NPPC show better performances than previous proposed methods i.e. C-Support Classification(C-SVC) One-class SVM detection HGT.