Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

作者: S. Padilla , D. Corum , B. Padnos , D.L. Hunter , A. Beam

DOI: 10.1016/J.REPROTOX.2011.10.018

关键词: Developmental toxicityPotencyToxicologyPharmacologyEmbryoChemical libraryZebrafishDanioBiologyToxicityComputational toxicology

摘要: … For some pairs, both the parent chemical and the metabolite were toxic to the developing zebrafish embryo (eg., methoxychlor, metam-sodium, chlorpyrifos ethyl and their active …

参考文章(82)
Jon A. Arnot, Michelle Arnot, Donald Mackay, Yves Couillard, Drew MacDonald, Mark Bonnell, Pat Doyle, Molecular size cutoff criteria for screening bioaccumulation potential: Fact or fiction? Integrated Environmental Assessment and Management. ,vol. 6, pp. 210- 224 ,(2007) , 10.1897/IEAM_2009-051.1
Kimberly C. Brannen, Julieta M. Panzica-Kelly, Tracy L. Danberry, Karen A. Augustine-Rauch, Development of a zebrafish embryo teratogenicity assay and quantitative prediction model. Birth Defects Research Part B-developmental and Reproductive Toxicology. ,vol. 89, pp. 66- 77 ,(2010) , 10.1002/BDRB.20223
Kerri A. Stanley, Lawrence R. Curtis, Staci L. Massey Simonich, Robert L. Tanguay, Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development Aquatic Toxicology. ,vol. 95, pp. 355- 361 ,(2009) , 10.1016/J.AQUATOX.2009.10.008
Latoya T. Thomas, Lillian Welsh, Fernando Galvez, Kurt R. Svoboda, Acute nicotine exposure and modulation of a spinal motor circuit in embryonic zebrafish. Toxicology and Applied Pharmacology. ,vol. 239, pp. 1- 12 ,(2009) , 10.1016/J.TAAP.2008.08.023
Thomas B. Knudsen, Keith A. Houck, Nisha S. Sipes, Amar V. Singh, Richard S. Judson, Matthew T. Martin, Arthur Weissman, Nicole C. Kleinstreuer, Holly M. Mortensen, David M. Reif, James R. Rabinowitz, R. Woodrow Setzer, Ann M. Richard, David J. Dix, Robert J. Kavlock, Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. Toxicology. ,vol. 282, pp. 1- 15 ,(2011) , 10.1016/J.TOX.2010.12.010
Sharon L. Oxendine, John Cowden, David E. Hinton, Stephanie Padilla, Adapting the medaka embryo assay to a high-throughput approach for developmental toxicity testing. Neurotoxicology. ,vol. 27, pp. 840- 845 ,(2006) , 10.1016/J.NEURO.2006.02.009
Des W. Connell, Darryl W. Hawker, Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish. Ecotoxicology and Environmental Safety. ,vol. 16, pp. 242- 257 ,(1988) , 10.1016/0147-6513(88)90054-1
Matthew T Martin, Thomas B. Knudsen, David M. Reif, Keith A. Houck, Richard S. Judson, Robert J. Kavlock, David J. Dix, Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening Biology of Reproduction. ,vol. 85, pp. 327- 339 ,(2011) , 10.1095/BIOLREPROD.111.090977
Cornelia Kienle, Heinz-R. Köhler, Almut Gerhardt, Behavioural and developmental toxicity of chlorpyrifos and nickel chloride to zebrafish (Danio rerio) embryos and larvae. Ecotoxicology and Environmental Safety. ,vol. 72, pp. 1740- 1747 ,(2009) , 10.1016/J.ECOENV.2009.04.014
Graham J. Lieschke, Peter D. Currie, Animal models of human disease: zebrafish swim into view Nature Reviews Genetics. ,vol. 8, pp. 353- 367 ,(2007) , 10.1038/NRG2091