The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector.
作者： B Hogh , M Dgedge , A Gamage-Mendis , J Barreto , G A Butcher
DOI: 10.4269/AJTMH.1998.58.176
关键词: Pyrimethamine-Sulfadoxine 、 Infectivity 、 Chloroquine 、 Gametocyte 、 Microbiology 、 Virology 、 Sulfadoxine 、 Malaria 、 Biology 、 Pyrimethamine 、 Plasmodium falciparum
摘要: Using serum or infected blood from Danish volunteers and Plasmodium falciparum-infected Mozambican patients, respectively, the impact of curative doses chloroquine pyrimethamine/sulfadoxine upon infectivity P. falciparum to Anopheles arabiensis An. gambiae berghei stephensi was studied. Both treatments cleared circulating gametocytes within 28 days. Before this clearance, enhanced arabiensis, whereas decreased infectivity. Patients harboring chloroquine-resistant parasites as opposed -sensitive ones were 4.4 times more likely have following treatment. In contrast, pyrimethamine/sulfadoxine-resistant 1.9 less produce gametocytes. laboratory infections using replicated preparations, chloroquine-treated, uninfected, nonimmune gametocyte with increasing efficiency for 21 days treatment, significantly suppressed The observed enhancement in induced by use combined increased gametocytemias strains may part explain rapid spread resistance endemic populations.
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