Trichinosis-related polyarteritis nodosa

摘要: Abstract During an outbreak of trichinosis, two young men—one with established trichinosis and the other suspected infection—were found to have clinical, radiologic histologic stigmata a systemic necrotizing vasculopathy equivalent classic polyarteritis nodosa. The parasitosis manifested as pentad fever, myalgias, facial edema, eosinophilia hyperimmunoglobulinemia E. Features arteritis included mononeuritis multiplex, pain in abdomen joints, weight loss, hypertension, leukocytosis, thrombocytosis, microhematuria raised alkaline phosphatase levels. A sustained remission was achieved by administration thiabendazole, prednisone cyclophosphamide. Pathogenetic links between diseases are presented: (1) deposition circulating immune complexes vessel wall; (2) adjuvant activity cross reaction parasitic antigen human (3) immunoglobulin E (IgE) aggregates soluble IgE precipitation (4) hypereosinophilia-induced tissue damage. causal relationship nodosa is persuasive, we suggest that cases hepatitis B surface (HBsAg) negative nodosa, especially those which myalgias prominent, may be related that, conversely, patients multiorgan disease should studied for