作者: Leo P. ten Kate , Marieke E. Teeuw , Lidewij Henneman , Martina C. Cornel
DOI: 10.1159/000360761
关键词: Demography 、 Endogamy 、 Consanguinity 、 Demographic history 、 Historical Article 、 Immigration 、 Public opinion 、 MEDLINE 、 Genetic counseling 、 Geography
摘要: This paper reviews what is currently known about the presence of consanguinity and endogamy in Netherlands, past today, concludes with a discussion medical genetic aspects. First geographic characteristics, demographic history, make-up native population, legal aspects public opinion are reviewed. Then data on prevalence population presented for marriages since 1840, followed by consanguineous among immigrants from countries tradition close-kin marriages. It estimated that approximately 1% at-risk couples referred to clinical centres prospective counselling Netherlands. picture will change dramatically if when next-generation sequencing introduced identify at ≥ 25% risk prospectively.