Cell Trafficking Networks in Cutaneous T Cell Lymphoma

摘要: An extensive network of Thy-1+/Factor XIIIa+ dermal dendrocytes (DD) (Table 1) exists within the papillary dermis in lesions cutaneous T cell lymphoma (CTCL). To further characterize these cells and to study role that activation signals adhesion molecules play cellular dynamics CTCL, immunohistochemical staining formalin fixed, paraffin embedded tissue sections was used expression high endothelial antigen-1 (HECA-452) proliferating nuclear antigen (PCNA) CTCL as compared those psoriasis, Rhus dermatitis normal skin. In diseased skin, 10–60% epidermotropic lymphocytes were PCNA+, comparable numbers Ki-67+ human mucosal leukocyte (HML)-1+ seen previous studies. HECA-452 by ranged from 1–42%. Only appreciable epidermal HECA-452+ present (mean = 31%+). PCNA+ routinely only limited a subset epidermis.