Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules

摘要: The present invention includes a formulation and dosage form for enhancing the bioavailability of orally administered hydrophilic macromolecules. permeation enhancer, macromolecule, carrier that exhibits in-situ gelling properties, such as nonionic surfactant. is delivered within GI tract liquid having at least some affinity surface mucosal membrane. Once released, it believed spreads across one or more areas membrane, where then transitions into biodhesive gel in-situ. As bioadhesive gel, macromolecule enhancer membrane concentrations sufficient to increase absorption through over period time. incorporates may be designed provide controlled release desired