DNA +Pro : an Improved Progressive Multiple Sequence Alignment Algorithm for Evolutionary Analysis Using Combined DNA-Protein Sequences

摘要: Alignment of DNA and protein sequences is a basic tool in the study evolutionary, structural functional relationship among macromolecules. Present sequence alignment methods are somewhat error-prone, often producing systematic bias. Errors alignments sometimes lead to subsequent misinterpretation information genes, proteins genomes. In traditional algorithms, conducted separately. It has been long believed that phylogenetic signal disappears more rapidly from than encoded proteins. therefore generally preferable align at amino acid level. Here we present new method—DNA^+Pro^, which aggregates into combined DNA-protein them fashion. We demonstrate combining improve quality multiple solve practical evolutionary problems primate immunodeficiency virus bacterial restriction enzymes. addition increased theoretical contents, distance estimations biological significant only or alignments. By integrating buried separately sequences, DNA^+Pro^ improves accuracy closely-related prevents certain errors may occur phylogeny analysis using approaches. The software supplementary data downloadable free charge "our website, http://www.dnapluspro.com":http://www.dnapluspro.com.