Educational level, management and outcomes in small-cell lung cancer (SCLC): A population-based cohort study.

作者: Salomon Tendler , Marit Holmqvist , Gunnar Wagenius , Rolf Lewensohn , Mats Lambe

DOI: 10.1016/J.LUNGCAN.2019.11.008

关键词: Lower riskPopulationPerformance statusHazard ratioInternal medicinePopulation studyLung cancerMedicineConfidence intervalCohort study

摘要: Abstract Objectives To examine if educational status is associated with outcome in patients Small Cell Lung Cancer (SCLC). The study also investigated differences patterns of management (lead times and treatment intensity) between levels. Material methods This nationwide cohort was based on data from Data Base Sweden (LCBaSe) generated by record linkages the Swedish National Register several other population-based registers. Educational level categorized number years schooling: low (≤ 9 years), medium (10–12 years) high (≥ 13 years). Risk death expressed as hazard ratios (HR) 95 % confidence interval (CI) were estimated multi-variable analyses adjusted for age, sex, disease stage at diagnosis, household size performance (PS). Analyses stratified sex performed. Results conclusions population encompassed 4256 an SCLC diagnosis 2002 2011. Higher education a significantly lower risk univariable multivariable models. HR comparing to 0.84 (95 CI: 0.75–0.93), estimate that attenuated following adjustments (HR 0.88; 0.80–0.98). Compared men education, education; 0.73–0.98). In Limited Disease (LD), prognosis better both women compared 0.76; 0.58–0.98). SCLC, among LD-SCLC, poorer education.

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