Self-assembly and biophysical properties of gemini 3-alkyloxypyridinium amphiphiles with a hydroxyl-substituted spacer.
作者： Vinay Chauhan , Sukhprit Singh , Taranjeet Kaur , Gurcharan Kaur
DOI: 10.1021/LA5045267
关键词: Pyridinium 、 Isothermal titration calorimetry 、 Agarose gel electrophoresis 、 Analytical chemistry 、 Crystallography 、 Alkyl 、 Bromide 、 Chemistry 、 Dynamic light scattering 、 Conductometry 、 Ethidium bromide
摘要: New gemini pyridinium amphiphiles having alkyl chain lengths of C10, C12, C14 , and C16 appended with hydroxyl-substituted spacers have been synthesized, characterized, investigated for their self-assembly as well adsorption behavior by state-of-the-art techniques such conductometry, tensiometry, isothermal titration calorimetry (ITC), spectrofluorometry. Dynamic light scattering (DLS) transmission electron microscopy (TEM) provided excellent acumen respect to the micellar size distribution dicationics in aqueous media. Furthermore, interaction these plasmid DNA, at different charge ratios (N/P), has studied DLS, agarose gel electrophoresis, ethidium bromide exclusion measurements. The cytotoxicity geminis evaluated using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on BV2 (microglial) C6 glioma cell lines. It was found that varying length, fashioned b...
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