Validation of 3-D finite element analysis for predicting the density distribution of roll compacted pharmaceutical powder

摘要: Abstract This study compares the density results from three-dimensional FEM simulations of a roll compaction process to those measured experimentally. Unlike previous studies, experiments were performed with an air-powered piston feeder configuration that applied known, uniform stress on powder. All model boundary conditions based experimentally-measured values. To further improve accuracy, also utilized density-dependent stress–strain constitutive parameters describe powder mechanical behaviors. Results show agree well corresponding experimental data. Important trends are successfully captured by simulations, including ribbon width-wise distribution and observation average was independent inlet when system operated at allowed gap ‘float’. Further, as result cantilevered shaft supports, rolls not perfectly parallel so slightly asymmetrical against half-width. Incorporating non-parallel configurations in resulted similar observations.