Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease

摘要: Background: It is often suggested that chronic wasting diseases [eg, obstructive pulmonary disease (COPD)] may benefit from branched-chain amino acid (BCAA) administration via improved protein metabolism. Objective: The aim was to examine whether adding BCAAs a soy meal would enhance anabolism in COPD patients and healthy elderly persons. Design: Eight normal-weight 8 control subjects were examined on 2 test days. Simultaneous continuous intravenous infusion of L-[ring- H 5 ]phenylalanine (Phe) ]tyrosine tracers done postabsorptively at h ingestion maltodextrin or + BCAA (rate ingestion: 0.02 g protein·kg body weight -1 ·20 min ) crossover design. Together with the meal, oral 1-[ 13 C]Phe performed measure first-pass Phe splanchnic extraction (SPE ). endogenous rate appearance [reflecting whole-body breakdown (WbPB)], synthesis (WbPS), net WbPS (WbPS - WbPB) calculated. Arterialized venous blood sampled for enrichment concentration analyses. Results: Soy feeding induced reduction WbPB an increase WbPS. supplementation resulted significantly higher (P < 0.05) than did alone but not elderly. alter change Furthermore, decreased (absolute) SPE percentage hydroxylation area, which indicates BCAA-related synthesis. Conclusion: enhances alters interorgan metabolism favor peripheral (muscle) compartment even more patients.