Discrete modelling of p53-Mdm2 feedback loop
作者： Jamil Ahmad , Umar Khan Niazi , Syeda Uzma Ali
关键词: P53 mdm2 、 Control theory 、 Feedback loop 、 Neuroscience 、 Gene regulatory network 、 Mdm2 、 Biology 、 DNA damage 、 Discrete modelling 、 Gene 、 Oscillation (cell signaling)
摘要: Cancer is the leading cause of death worldwide. The p53 gene play important role in suppression tumours. central protein DNA damage response and a part complex regulatory network. This network integrates variety stress signals to produce up-regulation active elicit apoptosis, growth arrest repair. In this paper, we construct discrete model involving its inhibitor Mdm2, use it examine effect stresses that trigger p53. demonstrates specific output behaviours steady states with high levels Mdm2 cycle (oscillation) low or levels.
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