Prognostic and predictive effect of microsatellite instability (MSI) in MAGIC

摘要: 62 Background: MSI is prognostic for survival in diverse cancers and predicts resistance to fluoropyrimidine chemotherapy colon cancer. We examined the interaction between patient (pt) characteristics pts randomised surgery alone or perioperative ECF MRC MAGIC trial. Methods: Tumor normal control DNA was extracted from resection FFPE. status determined using Promega Analysis System (NR-21, BAT-26, BAT-25, NR-24, MONO-27). Tumors were classified as MSS when all markers stable, MSI-L only one marker unstable MSI-H with minimum of instability two markers. correlated pt survival. Results: results available 303 (66% resected pts). Twenty (6.6%) 2 (0.6%) MSI-L. All had stomach tumors (vs.GEJ/esophagus). KRAS mutation more common tumours (30% vs. 4%, p-value <0.001); rates BRAF, PIK3CA TP53 mutations com...