Mixed acinar-endocrine carcinomas of the pancreas.

摘要: Acinar cell carcinoma is a rare pancreatic neoplasm that may contain scattered endocrine cells in as many 40% of cases. In addition, unusual tumors exist which the acinar and components each constitute significant proportion (> 25%) neoplasm; we propose to designate them "mixed acinar-endocrine carcinomas." study five such cases, found one case with segregated areas were identifiable routinely stained sections four cases morphologically uniform populations where divergent differentiation was only detected immunohistochemically. The occurred adults (age range, 48-81; mean, 68); there two men three women. None patients presented symptoms related either enzyme or hormone liberation. Histologically, very cellular; various combinations solid, trabecular, acinar, glandular growth patterns noted. contained d-PAS-positive granules showed immunohistochemical positivity for enzymes (trypsin, chymotrypsin, lipase) markers (chromogranin synaptophysin); specific hormones Double staining most expressed line differentiation. Ultrastructural granules. Two died their (mean survival, 10.5 months), widespread metastases. alive disease at 12 months after diagnosis, patient lost follow-up 3 months. This type provides further evidence close histogenetic relationship between exocrine this organ.