Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits

摘要: Cell-type specific differences in the kinetics of inhibitory postsynaptic conductance changes (IPSCs) are believed to impact upon network dynamics throughout brain. Much attention has focused on how GABAA receptor (GABAAR) alpha and beta subunit diversity will influence IPSC kinetics, but less is known about gamma subunit. We have examined whether GABAAR heterogeneity influences properties thalamus. The gamma2 gene was deleted from GABAARs selectively dorsal lateral geniculate nucleus (dLGN). removal dLGN reduced overall sIPSC frequency across all relay cells produced an absence IPSCs a subset neurons. remaining slower were both insensitive diazepam zinc indicating Because these potentiated by DMCM, we propose involve gamma1 subunit-containing activation. Therefore, appears GABAAR-mediated synaptic transmission visual thalamus cell-selective manner. suggest that activation give rise general, while faster tend be mediated GABAARs.