Microregional expression of glucose transporter-1 and oxygenation status: lack of correlation in locally advanced cervical cancers.

摘要: Purpose: Glucose transporter-1 ( GLUT-1 ), a target gene of hypoxia-inducible factor-1, has been considered candidate endogenous marker tumor hypoxia. Expression may also serve as an indicator for the induction transcriptional response to hypoxia, which linked enhanced proliferation, resistance therapy, and metastatic propagation cancer cells. Overexpression shown correlate with poor prognosis in several entities, among them cancers uterine cervix. The validity these hypotheses is investigated. Experimental Design: expression was assessed 80 biopsies Eppendorf oxygenation measurement tracks from locally advanced cervical 47 patients using immunohistochemistry. Results: No correlation found between variables (median p O 2 , HF 2.5 5). greater larger tumors P = 0.0001) exhibit linear increase Federation Internationale de Gynecologie et d9 Obstetrique stage 0.002). Overall survival 0.004) recurrence-free 0.007) were significantly shorter GLUT-1. In subgroup treated surgery, this effect on not independent when pT or pN included multivariate Cox proportional hazards model. Conclusions: suitability hypoxia seems questionable. association partially depend confounding factors.