Familial pancreatic cancer.

摘要: Context Approximately 5% to 10% of individuals with pancreatic cancer report a history in close family member. In addition, several known genetic syndromes, such as familial breast (BRCA2), the Peutz-Jeghers syndrome, and atypical multiple mole melanoma have been shown be associated an increased risk cancer. The genes these conditions can explain only portion clustering families, research identify additional susceptibility is ongoing. Objective To provide understanding pathology exocrine cancers. Data sources Published literature on aggregation tumors. Conclusions Even absence predictive testing, collection careful, detailed important step management all patients While most cancers that arise are ductal adenocarcinomas, certain subtypes syndromes. Therefore, histologic appearance itself, and/or presence precancerous changes pancreas, may increase clinical index suspicion for syndrome.