Rod Vision Is Controlled by Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA

摘要: Summary Dark and light adaptation of retinal neurons allow our vision to operate over an enormous intensity range. Here we report a mechanism that controls the sensitivity operational range rod-driven bipolar cells mediate dim-light vision. Our data indicate responses these are enhanced by sustained chloride currents via GABA C receptor channels. This sensitizing GABAergic input is controlled dopamine D1 receptors, with horizontal serving as plausible source release. findings expand role in from its well-established function suppressing signals bright enhancing same under dim illumination. They further reveal for circuitry vision, thereby complementing GABA's traditional providing dynamic feedforward feedback inhibition retina.