Stromal Cell Niches in the Inflamed Central Nervous System.

摘要: Inflammation in the CNS must be tightly regulated to respond efficiently infection with neurotropic pathogens. Access of immune cells and their positioning within tissue are controlled by stromal that construct barriers CNS. Although role endothelium regulating passage leukocytes small molecules into has been studied extensively, contribution fibroblastic as portals entry was only recently uncovered. We review critical immune-stimulating meningeal fibroblasts promoting recruitment retention lymphocytes during inflammation. Activated have capacity rapidly elaborate an immune-competent niche sustains protective entering from draining cervical lymph node. Such cell niches can ultimately foster establishment tertiary lymphoid tissues chronic neuroinflammatory conditions.