Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.

作者: Xu Wu , Tong Zhang , Julie Bossuyt , Xiaodong Li , Timothy A McKinsey

DOI: 10.1172/JCI27374

关键词: BiologyCalmodulinCardiac myocyteVoltage-dependent calcium channelCa2+/calmodulin-dependent protein kinaseCalcium signalingCell biologyBiochemistryNuclear export signalPhosphorylationHistone deacetylase 5

摘要: Previous work showed that calmodulin (CaM) and Ca 2+ -CaM–dependent protein kinase II (CaMKII) are somehow involved in cardiac hypertrophic signaling, that inositol 1,4,5-…

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