Significance of EGFR Expression in Circulating Tumor Cells.
作者： María José Serrano , María Jesús Alvarez-Cubero , Diego De Miguel Pérez , Alba Rodríguez-Martínez , Lucas Gonzalez-Herrera
DOI: 10.1007/978-3-319-55947-6_16
关键词: Cancer cell 、 Epidermal growth factor receptor 、 Circulating tumor cell 、 Cancer 、 Motility 、 Metastasis 、 Immunology 、 Mutation 、 Biology 、 Cancer research 、 Gene expression
摘要: This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role cancer progression, genetic changes related to metastasis , resistance treatment. The aberrant behavior is caused by mutations altered patterns gene expression. These can be responsible for an increase cell motility but also ability CTCs survival different microenvironments, as well developing therapy-resistant clones. Finally, acquire invade distant organs, where metastatic foci develop.
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