Pyrrolidinones derived from (S)-pyroglutamic acid. Part 1. Conformationally constrained glutamate
作者： Jonathan H. Bailey , David T. Cherry , James Dyer , Mark G. Moloney , Mark J. Bamford
DOI: 10.1039/B001999M
关键词: NMDA receptor 、 Lactam 、 Agonist 、 Pyroglutamic acid 、 Bicyclic molecule 、 Stereochemistry 、 Pyrrolidinones 、 Ring (chemistry) 、 Total synthesis 、 Chemistry
摘要: Novel conformationally constrained pyroglutaminols and pyroglutamates are readily available using an α,β-unsaturated bicyclic lactam as a template for diastereocontrolled enolate additions in the key step; zinc enolates particularly effective this regard. The ring system both controls permits determination of stereochemistry. utility methodology is demonstrated by formal total synthesis NMDA receptor agonist, CPAA 11.
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