Cardiac magnetic field map topology quantified by Kullback-Leibler entropy identifies patients with hypertrophic cardiomyopathy.

摘要: Hypertrophic cardiomyopathy (HCM) is a common primary inherited cardiac muscle disorder, defined clinically by the presence of unexplained left ventricular hypertrophy. The detection affected patients remains challenging. Genetic testing limited because only in 50%–60% all HCM diagnoses an underlying mutation can be found. Furthermore, disease has varied clinical course and outcome, with many having little or no discernible cardiovascular symptoms, whereas others develop profound exercise limitation recurrent arrhythmias sudden death. Therefore prospective screening family members strongly recommended. According to current guidelines this includes serial echocardiographic electrocardiographic examinations. In study we investigated capability magnetic field mapping (CMFM) detect suffering from HCM. We introduce for first time combined diagnostic approach based on map topology quantification using Kullback-Leibler...