Human sodium channel isoforms
作者： Samuel C Dudley , Li-Juan L Shang
DOI:
关键词: Biology 、 Sodium channel 、 Untranslated region 、 Start codon 、 Molecular biology 、 Gene isoform 、 Genetics 、 Increased risk 、 Messenger RNA
摘要: The present invention relates to novel isoforms in or near the 5' untranslated region (upstream of start codon) and 3' (down stream which correlates with an increased risk heart disease. These are various spliced variants wild-type sodium channel mRNA. Preferably, that correlate disease E1B1 (SEQ ID NO. 1), E1B2 2), E1B3 3), E1B4 4), E2B1 5), E2B2 6), E28B 7), E28C 8), E28D 9).
lens.org 参考文章(19)
Jo Ann Kop, Sherrol Hoffa Mcdonough, James John Hogan, Richard Dana Smith, Nucleic acid probes for detection and/or quantitation of non-viral organisms ,(1994)
Lisa Wodicka, David J. Lockhart, Ming Hsui Ho, Exploiting genomics in the search for new drugs ,(1998)
Jonathan C. Makielski, Michael J. Ackerman, Bin Ye, Sodium channel alpha subunit variants ,(2003)
Paul Bartel, Daniel A. Wettstein, Karen Heichman, Janice Sugiyama, Daniel Cimbora, Compositions and methods for treating diseases ,(2007)
Michael Ackerman, Method of genetic testing in heritable arrhythmia syndrome patients ,(2004)
Mark E. Curran, Mark T. Keating, Qing Wang, Long QT syndrome genes Biotechnology Advances. ,vol. 15, ,(1995)
Arshed Quyyumi, Samuel Dudley, David Harrison, Tai-Hwang Fan, Methods and compositions for treating diastolic dysfunction ,(2007)
Joshua Hare, Michelle Kittleson, Identification of gene expression by heart failure etiology ,(2006)
Bin Ye, Jonathan C. Makielski, Sodium channel alpha subunits ,(2003)
Jr. Samuel C. Dudley, Modulation of sodium channels by nicotinamide adenine dinucleotide ,(2008)