Epidemiology of systemic vasculitis

摘要: The systemic vasculitides are heterogeneous conditions of unknown etiology characterized by inflammation and necrosis different sized blood vessels. Wegener’s Granulomatosis, microscopic polyangiitis, Churg Strauss syndrome associated with anti-neutrophil cytoplasmic antibodies affect small medium They very rare in childhood peak the 65 to 70 year old age group. Granulomatosis appears be more common North Europe compared South. All whites other populations. Genetic environmental factors, including infection, drugs, silica, important etiology. Giant cell arteritis is predominantly a disease over 50. It individuals Nordic descent. Incidence may increasing time cyclical variation reflect an infectious Takayasu aorta its branches, however pulmonary cardiac arteries involved. Patients usually under 40-years at presentation there no apparent differences incidence or clinical characteristics/aortic involvement across globe. Kawasaki (KD) Henoch-Schonlein purpura diseases children rarely adults. Both have been reported Asians than whites. KD higher Japan China regions. No definite trigger factors found, but has linked house dust mite chemicals, pesticide drugs.