Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes

摘要: The Fas/CD95 surface receptor mediates rapid death of various cell types, including autoreactive T cells with the potential for triggering autoimmunity. Here, we present novel aspects Fas signalling that define a 'social' dimension to receptor-induced apoptosis. stimulation rapidly induces extensive membrane nanotube formation between neighbouring cells. This is critically dependent on Rho GTPases but not caspase activation. Bidirectional transfer and cytosolic elements active caspases can be observed occur via these nanotubes. Nanotube intercellular exchanges signals are defective in lymphocytes from patients autoimmune lymphoproliferative syndrome harbouring mutations receptor. We conclude nanotube-mediated constitute form communication augments propagation