Primary aldosteronism is associated with decreased low-density and high-density lipoprotein particle concentrations and increased GlycA, a pro-inflammatory glycoprotein biomarker

摘要: Background: Primary aldosteronism (PA) may confer increased cardiovascular risk beyond effects on systemic blood pressure, but contributing mechanisms remain incompletely understood. We compared plasma (apo)lipoproteins and lipoprotein particle characteristics, GlycA, a pro-inflammatory glycoprotein biomarker of enhanced chronic inflammation, total branched-chain amino acids (BCAA), measured using nuclear magnetic resonance (NMR) spectroscopy, between patients with PA, control subjects without hypertension, untreated hypertension treated hypertension.  Methods: Twenty PA were individually matched 2819 501 878 participating in the PREVEND (Prevention Renal Vascular End-Stage Disease) cohort study respect to age, sex, body mass index, smoking statin use. The Vantera (R) Clinical Analyzer was used determine NMR-based laboratory parameters.  Results: Total cholesterol, low-density cholesterol (LDL-C), high-density (HDL-C), apolipoprotein (apo) B, A-I (apoA-I), LDL HDL concentrations all decreased vs (P <0.016). Triglycerides (TG) triglyceride-rich (TRL) lower (untreated) hypertension. GlycA three comparator groups BCAA unaltered PA.  Conclusions: is associated particles some extent also TG TRL concentrations. characterized by levels, indicating low-grade inflammation. Low could contribute accelerated disease development PA.