Replication of the B19 parvovirus in human bone marrow cell cultures.
作者： K Ozawa , G Kurtzman , N Young
关键词: Bone marrow 、 Erythropoietin 、 Parvoviridae 、 Parvovirus 、 Cell culture 、 Viral replication 、 Virus 、 Biology 、 Virology 、 In vitro
摘要: The B19 parvovirus is responsible for at least three human diseases. virus was successfully propagated in suspension cultures of erythroid bone marrow from patients with hemolytic anemias; release newly synthesized into the supernatants infected observed. This culture system allowed study a molecular level events associated life cycle. replicated through high weight intermediate forms, linked terminal hairpin structure. replication vitro highly dependent on erythropoietic content and addition hormone erythropoietin.
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