In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration.
作者： Shunmugaperumal Tamilvanan , Sven Schmidt , Rainer H. Müller , Simon Benita
DOI: 10.1016/J.EJPB.2004.07.001
关键词: Oleylamine 、 Emulsion 、 Deoxycholic acid 、 Chemical engineering 、 Surface charge 、 Adsorption 、 Cationic polymerization 、 Chemistry 、 Oleic acid 、 Protein adsorption 、 Chromatography
摘要: Surface (charge) modified submicron emulsions (cationic and anionic) were prepared following the well established combined emulsification techniques characterized for their droplet size distribution surface charge. The effect of these on in vitro adsorption plasma proteins was investigated by means two dimensional polyacrylamide gel electrophoresis (2D PAGE). presence poloxamer 188 tested effectively eliminated larger like immunoglobulins, fibrinogen, etc. However, depending type charges, smaller such as apolipoproteins albumin almost completely adsorbed onto emulsions. Indeed, when compared to marketed lipofundin MCT 10%-and deoxycholic acid-based anionic emulsions, apolipoprotein, especially apoA-1, approximately three times more stearylamine-and oleylamine-based cationic oleic In addition, ratio between apoA-1 apoA-IV found be 1 10% whereas it about 0.26 emulsion above 5 This indicates that having similar surface/interfacial charge imparted different anion-forming stabilizers (oleic or acids) exhibited markedly protein patterns.
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