Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis.

摘要: Patients with long-standing ulcerative colitis (UC) are at increased risk for colon cancer. These cancers thought to arise from preexisting dysplasia in a field of abnormal cells that often exhibits aneuploidy and p53 abnormalities. Using dual color fluorescence situ hybridization centromere probes locus-specific arm chromosomes 8, 11, 17, 18, we demonstrate chromosomal instability (CIN) is present throughout the UC patients high-grade or In rectal biopsies were negative dysplasia, abnormalities arms, especially losses, most common, whereas gains common The frequency type varied between examined; chromosome 8 was least affected, 17p loss found be an early frequent event. Chromosomal showed 100% sensitivity specificity distinguishing control histologically these patients, raising possibility screen CIN might detect subset who greatest development results suggest cancer process affects entire colon; this may provide mutator phenotype predisposes tumor suppressor genes evolution