Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer.
作者： Gnidyuk Mi , Shapochka Do , Zaletok Sp
DOI:
关键词: Cancer research 、 Receptor 、 Cancer 、 Breast cancer 、 Steroid hormone 、 Transcription factor 、 P50 、 Immunohistochemistry 、 NF-κB 、 Biology 、 Pathology
摘要: Aim: The aim of the present study was to investigate expression patterns transcription factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 p53 in tumor tissue patients with breast cancer (BC) analyze correlation between these markers. Patients Methods: 62 BC previously not treated chemo- or radiotherapy were included study. All tumors belong invasive ductal carcinoma different grade. Expression molecular markers determined by immunohistochemical analysis on paraffin-embedded sections. Results: grade defined. found be changed dependent PR also subtype (luminal, Her2-positive, hybrid, basal-like). highest levels NF-κB, Ki67 Her2/neu+ basal-like subtypes. Conclusion: increase nuclear correlates a decrease steroid hormone receptors (ER PR), accumulation, is associated Her2-positive types.
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