Protein inhalation powders: spray drying vs spray freeze drying.

作者: Yuh‐Fun Maa , Phuong‐Anh Nguyen , Theresa Sweeney , Steven J. Shire , Chung C. Hsu

DOI: 10.1023/A:1018828425184

关键词: Spray dryingParticle sizeParticle-size distributionAerosolSpecific surface areaChromatographyChemistryFreeze-dryingExcipientThermogravimetric analysis

摘要: … Supercritical fluid antisolvent (2,3) and spray freeze drying (4) … using spray freeze-dried protein powders for aerosolization. … in this study, spray drying and spray freeze drying, serve as a …

参考文章(9)
Yuh‐Fun Maa, Phuong‐Anh Nguyen, James D. Andya, Nancy Dasovich, Theresa D. Sweeney, Steven J. Shire, Chung C. Hsu, Effect of Spray Drying and Subsequent Processing Conditions on Residual Moisture Content and Physical/Biochemical Stability of Protein Inhalation Powders Pharmaceutical Research. ,vol. 15, pp. 768- 775 ,(1998) , 10.1023/A:1011983322594
Wayne R. Gombotz, Larry R. Brown, Michael S. Healy, Henry E. Auer, Process for producing small particles of biologically active molecules ,(1990)
David A Edwards, Justin Hanes, Giovanni Caponetti, Jeffrey Hrkach, Abdelaziz Ben-Jebria, Mary Lou Eskew, Jeffrey Mintzes, Daniel Deaver, Noah Lotan, Robert Langer, Large Porous Particles for Pulmonary Drug Delivery Science. ,vol. 276, pp. 1868- 1872 ,(1997) , 10.1126/SCIENCE.276.5320.1868
Sang-Do Yeo, Gio-Bin Lim, Pablo G. Debendetti, Howard Bernstein, Formation of microparticulate protein powder using a supercritical fluid antisolvent Biotechnology and Bioengineering. ,vol. 41, pp. 341- 346 ,(1993) , 10.1002/BIT.260410308
Michael A. Winters, Barbara L. Knutson, Pablo G. Debenedetti, H. Gerald Sparks, Todd M. Przybycien, Cynthia L. Stevenson, Steven J. Prestrelski, Precipitation of Proteins in Supercritical Carbon Dioxide Journal of Pharmaceutical Sciences. ,vol. 85, pp. 586- 594 ,(1996) , 10.1021/JS950482Q
Yuh-Fun Maa, Phuong-Anh T. Nguyen, Selena W. Hsu, Spray‐drying of air–liquid interface sensitive recombinant human growth hormone Journal of Pharmaceutical Sciences. ,vol. 87, pp. 152- 159 ,(1998) , 10.1021/JS970308X
Yuh-Fun Maa, Henry R. Costantino, Phuong-Anh Nguyen, Chung C. Hsu, The Effect of Operating and Formulation Variables on the Morphology of Spray-Dried Protein Particles Pharmaceutical Development and Technology. ,vol. 2, pp. 213- 223 ,(1997) , 10.3109/10837459709031441
Yuh-Fun Maa, Phuong-Anh Nguyen, Kin Sit, Chung C. Hsu, Spray‐drying performance of a bench‐top spray dryer for protein aerosol powder preparation Biotechnology and Bioengineering. ,vol. 60, pp. 301- 309 ,(1998) , 10.1002/(SICI)1097-0290(19981105)60:3<301::AID-BIT5>3.0.CO;2-L
A. J. Hickey, R. M. Platz, M. M. Van Oort, N. M. Concessio, FACTORS INFLUENCING THE DISPERSION OF DRY POWDERS AS AEROSOLS Pharmaceutical technology. ,vol. 18, pp. 58- 58 ,(1993)