Diuretics and mortality in acute renal failure*

摘要: Objective: According to recent research, diuretics may increase mortality in acute renal failure patients. The administration of such patients has been discouraged. Our objective was determine the impact on rate critically ill with failure. Design: Prospective, multiple-center, multinational epidemiologic study. Setting: Intensive care units from 54 centers and 23 countries. Patients: Patients were 1,743 consecutive who either treated replacement therapy or fulfilled predefined criteria for Interventions: Three distinct multivariate models developed assess relationship between diuretic use subsequent mortality: a) a propensity score adjusted model containing terms previously identified be important predictors outcome; b) new model; c) using standard methods, compensating collinearity. Measurements Main Results: Approximately 70% at study inclusion. Mean age 68 mean Simplified Acute Physiology Score II 47. Severe sepsis/septic shock (43.8%), major surgery (39.1), low cardiac output (29.7), hypovolemia (28.2%) most common conditions associated development Furosemide used (98.3%). Combination 98 only. In all three models, not significantly increased risk mortality. Conclusions: Diuretics are commonly prescribed failure, their is higher There full equipoise randomized controlled trial dysfunction. (Crit Care Med 2004; 32:1669 ‐1677)