Structural insights into CPT-11 activation by mammalian carboxylesterases.
作者： Sompop Bencharit , Christopher L. Morton , Escher L. Howard-Williams , Mary K. Danks , Philip M. Potter
DOI: 10.1038/NSB790
关键词: Carboxylesterase 、 Prodrug 、 Topoisomerase 、 Stereochemistry 、 Amino acid 、 Enzyme 、 Hydrolase 、 Chemistry 、 Leaving group 、 Glycosylation
摘要: … and end of the disordered regions of the structure (Phe 354, Lys 371, Glu 459 and His 467) are … Second, deep within the substrate-binding cavity, the four gate residues form the acyl site …
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researchgate.net 参考文章(38)
Sylvie M. Guichard, Monika Wierdl, Mary K. Danks, Erik. J. Krull, Philip M. Potter, Linda C. Harris, Rebecca A. Burger, Mandy M. Meck, Lars M. Wagner, A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11. Cancer Research. ,vol. 61, pp. 5083- 5089 ,(2001)
Judith S. Wolverton, Monika Wierdl, Mary K. Danks, Philip M. Potter, Christopher L. Morton, Cellular Localization Domains of a Rabbit and a Human Carboxylesterase: Influence on Irinotecan (CPT-11) Metabolism by the Rabbit Enzyme Cancer Research. ,vol. 58, pp. 3627- 3632 ,(1998)
Clayton W. Naeve, Cynthia A. Pawlik, Mary K. Danks, Philip M. Potter, Christopher L. Morton, Isolation and Partial Characterization of a cDNA Encoding a Rabbit Liver Carboxylesterase That Activates the Prodrug Irinotecan (CPT-11) Cancer Research. ,vol. 58, pp. 2646- 2651 ,(1998)
Jorge Navaza, Pedro Saludjian, [33] AMoRe: An automated molecular replacement program package Methods in Enzymology. ,vol. 276, pp. 581- 594 ,(1997) , 10.1016/S0076-6879(97)76079-8
Julie L. Eiseman, Monika Wierdl, Mary K. Danks, Philip M. Potter, Clinton F. Stewart, Christopher L. Morton, LaGora Oliver, Margaret K. Ma, Activation of CPT-11 in Mice: Identification and Analysis of a Highly Effective Plasma Esterase Cancer Research. ,vol. 60, pp. 4206- 4210 ,(2000)
W F Bosron, M R Brzezinski, L M Kamendulis, R A Dean, E V Pindel, Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases. Journal of Pharmacology and Experimental Therapeutics. ,vol. 279, pp. 713- 717 ,(1996)
Evgenia V. Pindel, Natalia Y. Kedishvili, Trent L. Abraham, Monica R. Brzezinski, Jing Zhang, Robert A. Dean, William F. Bosron, Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. Journal of Biological Chemistry. ,vol. 272, pp. 14769- 14775 ,(1997) , 10.1074/JBC.272.23.14769
Joseph D. Schrag, Miroslaw Cygler, 1.8 A refined structure of the lipase from Geotrichum candidum. Journal of Molecular Biology. ,vol. 230, pp. 575- 591 ,(1993) , 10.1006/JMBI.1993.1171
Marcello Lotti, Albert Ketterman, Lucy Waskell, Ronald E. Talcott, Meperidine carboxylesterase in mouse and human livers Biochemical Pharmacology. ,vol. 32, pp. 3735- 3738 ,(1983) , 10.1016/0006-2952(83)90143-0
James M. Joly, Thomas M. Brown, Metabolism of aspirin and procaine in mice pretreated with O-4-nitrophenyl methyl(phenyl)phosphinate or O-4-nitrophenyl diphenylphosphinate. Toxicology and Applied Pharmacology. ,vol. 84, pp. 523- 532 ,(1986) , 10.1016/0041-008X(86)90257-7