Long-Term Memory Formation in Drosophila Requires Training-Dependent Glial Transcription
作者： M. Matsuno , J. Horiuchi , Y. Yuasa , K. Ofusa , T. Miyashita
DOI: 10.1523/JNEUROSCI.3865-14.2015
关键词: Gene knockdown 、 Transcription (biology) 、 Premovement neuronal activity 、 Transcription factor 、 Cell type 、 Gene expression 、 Homeobox 、 Mutant 、 Cell biology 、 Biology 、 Molecular biology
摘要: Long-term memory (LTM) formation requires de novo gene expression in neurons, and subsequent structural functional modification of synapses. However, the importance glia during this process has not been well studied. In report, we characterize a cell adhesion molecule, Klingon (Klg), which is required for LTM Drosophila. We found that Klg localizes to juncture between neurons glia, both types LTM. further glial gene, repo, reduced klg mutants knockdown lines. repo LTM, increases upon induction. addition, increasing sufficient restore These data indicate neuronal activity enhances Klg-mediated neuron-glia interactions, causing an increase repo. Repo homeodomain transcription factor, suggesting downstream also
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